David E Birk Selected Research

Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos)

1/2021	Type V collagen regulates the structure and biomechanics of TMJ condylar cartilage: A fibrous-hyaline hybrid.
1/2021	Collagen XII mediated cellular and extracellular mechanisms regulate establishment of tendon structure and function.
12/2017	Collagen V haploinsufficiency in a murine model of classic Ehlers-Danlos syndrome is associated with deficient structural and mechanical healing in tendons.
2/2016	Collagen V-heterozygous and -null supraspinatus tendons exhibit altered dynamic mechanical behaviour at multiple hierarchical scales.
1/2016	Altered dermal fibroblast behavior in a collagen V haploinsufficient murine model of classic Ehlers-Danlos syndrome.
6/2015	Regulatory role of collagen V in establishing mechanical properties of tendons and ligaments is tissue dependent.
5/2015	Targeted deletion of collagen V in tendons and ligaments results in a classic Ehlers-Danlos syndrome joint phenotype.
6/2011	Regulation of collagen fibril nucleation and initial fibril assembly involves coordinate interactions with collagens V and XI in developing tendon.
5/2006	Murine model of the Ehlers-Danlos syndrome. col5a1 haploinsufficiency disrupts collagen fibril assembly at multiple stages.
4/2006	Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis.

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David E Birk Research Topics

Disease

13	Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos) 01/2021 - 09/2002
4	Cicatrix (Scar) 01/2020 - 07/2009
4	Wounds and Injuries (Trauma) 01/2019 - 07/2009
4	Joint Instability (Joint Laxity) 06/2015 - 09/2002
3	Corneal Opacity 01/2019 - 07/2009
3	Muscular Diseases (Myopathy) 08/2014 - 04/2014
3	Muscle Weakness 08/2014 - 05/2013
2	Osteoarthritis 01/2020 - 08/2006
2	Inflammation (Inflammations) 01/2020 - 07/2009
2	Neoplasms (Cancer) 01/2017 - 05/2008
2	Contracture 06/2016 - 01/2011
2	Scleroatonic muscular dystrophy 01/2016 - 04/2014
2	Bethlem myopathy 01/2016 - 04/2014
2	Osteogenesis Imperfecta (Lobstein Disease) 06/2014 - 05/2004
2	Congenital Stromal Corneal Dystrophy 07/2013 - 11/2011
2	Muscular Dystrophies (Muscular Dystrophy) 05/2013 - 01/2011
2	Epidermolysis Bullosa 01/2005 - 10/2003
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2021
1	Obesity 01/2020
1	Heart Injuries 01/2020
1	Infarction (Infarctions) 01/2020
1	Acromicric dysplasia 01/2019
1	Heterotopic Ossification (Ectopic Ossification) 01/2018
1	recessive Cutis laxa 08/2015
1	Joint Dislocations 06/2015
1	Osteomalacia 06/2014
1	Tendon Injuries 03/2014
1	Protein Deficiency 05/2013
1	Pathologic Processes 05/2013
1	Blindness (Hysterical Blindness) 07/2009
1	Lung Neoplasms (Lung Cancer) 05/2008
1	Osteochondrodysplasias (Spondyloepiphyseal Dysplasia) 08/2006
1	Hypertrophy 08/2006
1	Autosomal Recessive Type VII Ehlers-Danlos Syndrome 04/2006
1	Cutis Laxa 03/2006
1	Epidermolysis Bullosa Dystrophica (Dystrophic Epidermolysis Bullosa) 01/2005
1	Chondrosarcoma 12/2004
1	Junctional Epidermolysis Bullosa (Epidermolysis Bullosa Letalis) 10/2003
1	Myopia 06/2003
1	Retinal Detachment (Retinal Detachments) 06/2003
1	Acquired Immunodeficiency Syndrome (AIDS) 09/2002

Drug/Important Bio-Agent (IBA)

25	CollagenIBA 01/2021 - 09/2002
5	Small Leucine-Rich ProteoglycansIBA 01/2020 - 11/2011
4	Collagen Type V (Type V Collagen)IBA 01/2021 - 05/2004
4	Proteoglycans (Proteoglycan)IBA 01/2020 - 09/2002
4	DecorinIBA 01/2020 - 11/2011
3	Proteins (Proteins, Gene)FDA Link 06/2014 - 12/2004
3	ProcollagenIBA 06/2014 - 01/2005
3	LumicanIBA 07/2009 - 09/2002
2	BiglycanIBA 01/2020 - 03/2014
2	IntegrinsIBA 01/2020 - 12/2004
2	Oxidoreductases (Dehydrogenase)IBA 01/2017 - 05/2008
2	Ferredoxins (Ferredoxin)IBA 01/2017 - 05/2008
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017 - 05/2008
2	Biological ProductsIBA 05/2013 - 04/2006
2	Collagen Type I (Type I Collagen)IBA 05/2006 - 05/2004
1	Conditioned Culture MediaIBA 01/2020
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	CilengitideIBA 01/2020
1	Versicans (Versican)IBA 01/2020
1	FibrillinsIBA 01/2019
1	Fibrillin-1IBA 01/2019
1	Metalloproteases (Metalloproteinases)IBA 01/2018
1	Fibronectins (Fibronectin)IBA 01/2016
1	alpha2 Subunit Collagen Type IIBA 06/2014
1	Messenger RNA (mRNA)IBA 04/2014
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2010
1	Insulin-Like Growth Factor I (IGF-1)IBA 09/2010
1	fragile histidine triad proteinIBA 05/2008
1	Matrilin ProteinsIBA 08/2006
1	Extracellular Matrix ProteinsIBA 08/2006
1	Peptide Hydrolases (Proteases)FDA Link 04/2006
1	ADAMTS ProteinsIBA 04/2006
1	Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA 03/2006
1	Collagen ReceptorsIBA 12/2004
1	Laminin (Merosin)IBA 10/2003
1	KalininIBA 10/2003
1	Peptides (Polypeptides)IBA 10/2003
1	FibromodulinIBA 09/2002

Therapy/Procedure

2	Therapeutics 12/2014 - 07/2009
1	Keratectomy 01/2019
1	Corneal Transplantation (Keratoplasty) 07/2009